Antagonistic role of barley against bioaccumulation and oxidative stress of aflatoxin B1 in male rats

Abstract Background This study aims to evaluate the protective effect of barley against bioaccumulation and oxidative stress aflatoxin B1 (AFB1) in male rats. The lethality percentile doses (LDs: LD1 LD99 at 24, 48, 72, 96 h) were measured. To achieve these goals during subacute treatments, one hundred rats divided into five groups, each with twenty groups I, II, III, IV, V throughout 21 days daily given drinking water, DMSO, 2.0 g barley/kg, 7.49 mg/kg AFB1 alone or combination respectively. Results results revealed that was detected only liver, kidney, serum which accumulated exhibited a significant direct relationship experimental periods marked positive correlation coefficient. Additionally, concentrations residue inverse levels GSH, activity CAT, SOD, GR, whereas MDA showed relationship. In plus barley, all parameters mostly recovered didn’t correlate either serum. Conclusions present data concluded accelerated biotransformation hydrophilic metabolite is easily eliminated outside body, leading recovery studied normal levels.